In this paper, we discuss challenges associated with implementing a policy for Ancillary Care (AC) for related and unrelated (serious) adverse events during an Ebola vaccine trial conducted in a remote area of the Democratic Republic of the Congo. Conducting clinical trials in resourceconstrained settings can raise context-related challenges that have implications for study participants’ health and wellbeing. During the Ebola vaccine study, three participants were injured in road traffic accidents, but there were unexpected difficulties when trying to apply the (...) AC policy. First, because of the nature of the adverse events, the insurer refused to cover the costs. Second, the AC policy did not address treatments by traditional medicine, even though traditional medicines are frequently used and highly trusted in the study community. This highlighted a contrast between the researchers’ well-intentioned AC approach and the participants’ legitimate preferences. The way in which researchers should address their responsibility to provide AC is not straightforward; it requires contextualization. Our experience highlights the importance of involving community representatives and the local ethics committee to ensure development of an AC policy that is culturally and ethically appropriate. Additionally, the insurance contract should clearly stipulate which adverse events are linked to the trial participation, and thus eligible for coverage, to avoid controversies when claims are made. (shrink)

In medical research, the ethical principle of respect for persons is operationalized into the process of informed consent. The consent tools should be contextualized and adapted to the different socio-cultural environment, especially when research crosses the traditional boundaries and reaches poor communities. We look at the challenges experienced in the malaria Quinact trial, conducted in the Democratic Republic of Congo, and describe some lessons learned, related to the definition of acceptable representative, the role of independent witness and the impact of (...) socio-economic vulnerability. To ensure children's protection, consent is required by the parents or, in their absence, by a legally mandated representative. In our setting, children's responsibility is often entrusted permanently or temporarily to relatives or friends without a tribunal mandate. Hence, a notion of ‘culturally acceptable representative’ under supervision of the local Ethics Committee may be more suitable. To ensure protection of illiterate subjects, an independent witness is required to confirm that the consent was freely given. However, in low-literacy contexts, potential witnesses often don't have any previous relationship with patient and there may be power-unbalance in their relationship, rather than genuine dialogue. In poor communities, trial participation may be seen as an opportunity to secure access to healthcare. Poverty may also lead to ‘competition’ to access the research-related benefits, with a risk of disturbance at societal or household level. Adjusting consent procedures to sociocultural and socioeconomic realities is essential for fulfilling the underlying ethical principles. This requires a collaborative dialogue between researchers, regulators and ethics committees. (shrink)

Prosocial compensation is a corporate social responsibility practice that involves donating money to a charitable cause on behalf of customers as a means to compensate them for their loss after a service failure. In order to determine the effectiveness of PC, we carried out three experiments while also comparing its effectiveness within private and public settings. Experiment 1 focused on the signaling effects of communicating the promise to offer PC to potential customers in the event of service failure. Results show (...) that, in both private and public settings, PC has positive effects on corporate image, credibility, and word-of-mouth intent. More significantly, PC improved one’s CSR image, whereas more tangible compensation, such as a gift voucher, did not. Experiments 2A and 2B focused on the effects of offering PC after a service failure on perceptions of justice. Results show that PC contributes to perceived distributive justice, procedural justice, and post-recovery satisfaction in both private and public settings. Our study showed that PC could be a relevant new CSR practice for organizations wanting to enhance theirs CSR image while contributing to fulfilling their ethical and philanthropic CSR responsibilities. We discuss the implications of our findings and offer several avenues for follow-up research on this initial study on PC. (shrink)

General relativity has a geometric and a field interpretation. If angular momentum conservation is invoked in the geometric interpretation to explain experiments, the causality principle is violated. The field interpretation avoids this problem by allowing faster-than-light propagation of gravity in forward time. All existing experiments are in agreement with that interpretation. This implies the existence of real superluminal propagation and communication of particles and fields, free of causality problems. The introduction of real physical faster-than-light propagation into gravitation, electrodynamics and quantum (...) theory has important consequences for physics. (shrink)

El artículo se propone rebatir la propuesta que planteó Allen Fromherz en uno de los últimos números de Al-Qanṭara, al identificar Īgīlīz-Des-Harġa, lugar de nacimiento de Ibn Tūmart y primer foco de la revolución almohade, con la localidad de Īglī, ubicada en el valle del Sous. Al juntar el estudio de la documentación escrita, la evocación historiográfica de los pocos estudios eruditos dedicados a este yacimiento desconocido, con los primeros elementos de una encuesta de geografía histórica y arqueológica en curso, (...) la presente contribución pretende demostrar : 1.º) que la teoría de Fromherz adolece de errores de apreciación de los materiales históricos empleados ; 2.º) que el pueblo natal de Ibn Tūmart no se ubica en el valle del Sous, sino en el Anti-Atlas central, tal como ya demostraron Huici Miranda y D. Jacques- Meunié ; 3.º) que el yacimiento de Īgīlīz-Des-Harġa, del cual se avanza aquí una ubicación precisa, encierra entre otros elementos un lugar fortificado de altura que sirvió de refugio a Ibn Tūmart y los miembros de su tribu durante los primeros enfrentamientos contra los Almorávides. Finalmente, se da una breve descripción arqueológica de los vestigios de este yacimiento inédito hasta ahora. (shrink)

Overzicht van de fundamentele vraagstukken van de politieke filosofie, een overzicht van het betreffende gedachtegoed van grote denkers en van actuele vraagstukken op dit terrein.

Information?rich environments are created to promote data use in schools for the purpose of self?evaluation and quality assurance. However, providing feedback does not guarantee that schools will actually put it to use. One of the main stumbling blocks relates to the interpretation and diagnosis of the information. This study examines the relationship between data literacy competences, support given in interpreting the information, actual use of the feedback and potential school improvement effect. A randomised field experiment with 188 school principals from (...) primary education was set up and a post?test was used to investigate the effects of a support initiative. The results revealed that a minority of schools invested significantly in the interpretation and diagnosis of the school performance feedback (SPF), despite the fact that most of the respondents showed an interest in the SPF report. In addition, data competence support and the subsequent use of feedback were found to be limited. (shrink)

On savait que c’était l’entité la plus complexe de l’univers connu. Mais le feu d’artifice de découvertes récentes dépasse l’entendement et fait exploser tous les schémas. Votre cerveau est (beaucoup) plus fabuleux que vous le croyez. Il est : totalement élastique, même âgé, handicapé, voire amputé de plusieurs lobes, le système nerveux central peut se reconstituer et repartir à l’assaut des connaissances et de l’action sur le monde ; totalement social, un cerveau n’existe jamais seul, mais toujours en résonance avec (...) d’autres. Mieux : nous sommes neuronalement constitués pour entrer en empathie avec autrui et aller à son secours. Ce livre aborde ces questions passionnantes avec cinq spécialistes. (shrink)

Limitations of antiarrhythmic drugs on cardiac sudden death prevention appeared since the early 80's. The "Cardiac Arrhythmia Suppression Trial"(CAST) showed more recently that mortality was significantly higher inpatients treated with some particular antiarrhythmic drugs than in non-treated patients. In this field, our group recently demonstrated that a bolus of a Class 1B antiarrhythmic drug was able to trigger a ventricular fibrillation due to transient blocks induction. The aim of the present work was to systematically study, by use of the van (...) Capelle and Durrer (VCD) model which allows to simulate ventricular activation wave propagation, the link between arrhythmogenic effects and the ability of transient blocks to possibly degenerate in severe arrhythmias. A fragment of the ventricular wall is represented by an array of 16384elements electrically coupled. Effects of induction of one or several transient blocks, as the effects of their size and duration on possible induction of reentries have been studied. Results obtained show that various combinations between these different parameters may trigger reentries, ventricular tachycardia and/or more complex patterns assimilable to ventricular fibrillation. These results clearly evidence the fact that possible induction of transient blocks may directly be related to risk factor associated to arrhythmogenic effects of antiarrhythmic drugs. (shrink)

" Tous les hommes désirent être heureux " et " nul ne saurait être heureux sans être vertueux " ; tels sont les principes de départ de l'éthique aristotélicienne. Mais comment les articuler? Et qu'entend exactement Aristote par " bonheur "? Les vertus sont des modes de comportement, comme le courage, la justice et l'amitié, et des activités de la raison, telles la prudence et la contemplation. Mais quel est précisément leur statut par rapport au bonheur? Ces questions correspondent aux (...) problématiques centrales de l'éthique d'Aristote ainsi qu'aux multiples interprétations et débats qu'elles suscitent depuis l'Antiquité. Les contributions de ce recueil se proposent d'en thématiser les enjeux. Contributions de Richard Bodéüs, Pierre Destrée, Jean-Louis Labarrière, David Lefebvre, Pierre Rodrigo, Gerd Van Riel, Marco Zingano. (shrink)

" Tous les hommes désirent être heureux " et " nul ne saurait être heureux sans être vertueux " ; tels sont les principes de départ de l'éthique aristotélicienne. Mais comment les articuler? Et qu'entend exactement Aristote par " bonheur "? Les vertus sont des modes de comportement, comme le courage, la justice et l'amitié, et des activités de la raison, telles la prudence et la contemplation. Mais quel est précisément leur statut par rapport au bonheur? Ces questions correspondent aux (...) problématiques centrales de l'éthique d'Aristote ainsi qu'aux multiples interprétations et débats qu'elles suscitent depuis l'Antiquité. Les contributions de ce recueil se proposent d'en thématiser les enjeux. Contributions de Richard Bodéüs, Pierre Destrée, Jean-Louis Labarrière, David Lefebvre, Pierre Rodrigo, Gerd Van Riel, Marco Zingano. (shrink)

Devant le constat du déclin toujours plus rapide de la diversité biologique et les limites des res- sources disponibles pour l’enrayer, il est nécessaire de déterminer quels moyens devraient être engagés dans sa protection. Pour ce faire, une méthode efficace serait d’évaluer les bénéfices tirés de la biodiversité afin d’estimer rationnellement les coûts légitimes de sa protection. L’évaluation économique, qui se présente d’emblée sur un mode quantitatif, serait alors un outil précieux. Dans ce texte, nous présentons différentes méthodes d’évaluation économique (...) de la biodiversité ainsi que certaines de leurs limites méthodologiques. Par la suite, nous montrons qu’en dépit de ses avantages pratiques, l’évaluation économique échoue à représenter l’ensemble des valeurs en jeu dans la protection de la biodiversité. Nous décrivons alors trois types de valeurs incommen- surables avec des bénéfices économiques : la valeur de legs, qui renvoie aux obligations de trans- mission du patrimoine naturel dont nous avons hérité ; la valeur d’existence, qui renvoie à la considération morale d’intérêts autres que ceux des êtres humains ; la valeur de transformation, qui renvoie à la capacité d’examiner et de critiquer nos préférences et inclinaisons afin d’inclure celles-ci dans une vision du monde rationnelle et cohérente. Pour conclure, nous plaidons en faveur de l’élaboration de méthodes de concertation et d’évaluation participatives et pluralistes permettant de rendre compte de la diversité et de l’hétérogénéité des valeurs de la biodiversité. (shrink)

VAN PRAAG (Paul), Introduction : le Père Henri Bosmans, histo­rien des mathématiques (pp. 7-16). SAUVAGE (Pierre), Notice biographique du Père Henri Bosmans (pp. 17-25). HERMANS (Michel), Henri Bosmans : sa formation et ses réseaux de rela­tions (pp. 27-72). DELANGHE (Richard), Quelques aspects de la vie et de l’œuvre de Paul Mansion (1844-1919) (pp. 73-82). BRIGAGLIA (Aldo), Saccheri vu par Corrado Segre en Italie et par Mansion et Bosmans en Belgique / traduit de l’italien par Bruna GAINO et Patricia RADELET-DE (...) GRAVE (pp. 83-104). MAWHIN (Jean), La tentative belge d’édition des œuvres complètes d’Euler vue par Henri Bos­mans (pp. 105-133). GOLVERS (Noël), Henri Bosmans, s.j., et la mission jésuite en Chine / traduit du néerlandais par Anne-Sophie MEURICE (pp. 135-152). ROMANO (Antonella), Henri Bosmans, jésuite et historien des mathéma­tiques dans la Belgique du premier XXe siècle (pp. 153-168). SAUVAGE (Pierre), Le Père Henri Bosmans et l’historiographie au tournant du XXe siècle (pp. 169-187). RADELET-DE GRAVE (Patricia), Le fonds Henri Bos­mans / avec un ajout de Michel HERMANS (pp. 189-215). MANSION (Paul), Correspondance de Paul Mansion adres­sée à Henri Bosmans / introduction, trans­cription et annotation par Michel HERMANS (pp. 217-251). HEEFFER (Albrecht) – HERMANS (Michel) – STOFFEL (Jean-François), Bibliographie d’Henri Bosmans (pp. 253-298). (shrink)

Marie-José Mondzain, philosophe, est directrice de recherche au CNRS. Elle a publié des livres sur l’image, entre autres, Image, icône, économie (Seuil, 1996), L’image peut-elle tuer? (Bayard, 2002), Le Commerce des regards (Seuil, 2003) ; des livres sur la peinture : Van Gogh ou la Peinture comme tauromachie (Éd. de l’Épure, 1996), Henri Cueco, vol. 2 (Cercle d’Art, 1997), L’Arche et l’Arc-en-ciel, Michel-Ange – la voûte de la chapelle Sixtine (Le Passage, 2006). Sa réflexion sur l’image l’a conduite à collaborer (...) avec des gens de théâtre et de cinéma, et à participer à des ouvrages collectifs : L’Assemblée théâtrale, 1 (Éd. de l’Amandier, 2002) et 2 ( La Représentation, Éd. de l’Amandier, 2004), Voir ensemble. Autour de Jean-Toussaint Desanti (Gallimard, 2003, coll. « Réfléchir le cinéma »), Le Cinéma et la Shoah. Un art à l’épreuve de la tragédie du xx e siècle (sous la dir. de J.-M. Frodon, Cahiers du Cinéma, 2007). Elle vient de publier Homo spectator (Bayard, 2007). (shrink)

Central to this volume are two philosophical powerhouses of the early modern period: Gottfried Wilhelm Leibniz and Pierre Bayle. Born in, respectively, 1646 and 1647, both made for an astonishing career in a variety of scholarly disciplines and reached, if not equal, then certainly comparable fame in the course of their lives. Nowadays, Bayle's reputation is eclipsed by that of Leibniz, who is the focus of yearly conferences and libraries of scholarship, while Bayle had to await the later twentieth (...) century to be rediscovered. He has since been at the center of a quickly expanding body of scholarship, which continues to be sharply divided over the vexed question how to interpret his religious stance.This imbalance... (shrink)

Here Jean-Pierre Changeux elucidates our current knowledge of the human brain, taking an interdisciplinary approach and explaining in layman's terms the complex theories and scientific breakthroughs that have significantly improved our ...

Par son enseignement et par ses traductions de Kant, Jean-Pierre Fussler a influencé plusieurs générations d'étudiants. Croisant les approches, ce recueil de travaux en son honneur fait dialoguer perspectives kantiennes, lectures et relectures des œuvres de Kant, commentaires de son œuvre et études de sa réception contemporaine, mais aussi, plus généralement, questions éthiques, essais phénoménologiques et diverses études philosophiques qui s'accordent toutes sur la nécessité de la méthode, la diversité du rationalisme et les impératifs de la pensée critique."--Page (...) 4 of cover. (shrink)

An examination of the fundamental role cybernetics played in the birth of cognitive science and the light this sheds on current controversies. The conceptual history of cognitive science remains for the most part unwritten. In this groundbreaking book, Jean-Pierre Dupuy—one of the principal architects of cognitive science in France—provides an important chapter: the legacy of cybernetics. Contrary to popular belief, Dupuy argues, cybernetics represented not the anthropomorphization of the machine but the mechanization of the human. The founding fathers (...) of cybernetics—some of the greatest minds of the twentieth century, including John von Neumann, Norbert Wiener, Warren McCulloch, and Walter Pitts—intended to construct a materialist and mechanistic science of mental behavior that would make it possible at last to resolve the ancient philosophical problem of mind and matter. The importance of cybernetics to cognitive science, Dupuy argues, lies not in its daring conception of the human mind in terms of the functioning of a machine but in the way the strengths and weaknesses of the cybernetics approach can illuminate controversies that rage today—between cognitivists and connectionists, eliminative materialists and Wittgensteinians, functionalists and anti-reductionists. Dupuy brings to life the intellectual excitement that attended the birth of cognitive science sixty years ago. He separates the promise of cybernetic ideas from the disappointment that followed as cybernetics was rejected and consigned to intellectual oblivion. The mechanization of the mind has reemerged today as an all-encompassing paradigm in the convergence of nanotechnology, biotechnology, information technology, and cognitive science. The tensions, contradictions, paradoxes, and confusions Dupuy discerns in cybernetics offer a cautionary tale for future developments in cognitive science. (shrink)

Suppose we were to meet with extraterrestrials and that we were able to have a discussion about our respective cultures. At some point, they start asking questions about that something which we call “mathematics”. “What is it?”, they ask. Tough question. How should we answer them?

Jean-Pierre Dupuy, prophet of what he calls "enlightened doomsaying," has long warned that modern society is on a path to self-destruction. In this book, he pleads for a subversion of this crisis from within, arguing that it is our lopsided view of religion and reason that has set us on this course. In denial of our sacred origins and hubristically convinced of the powers of human reason, we cease to know our own limits: our disenchanted world leaves us (...) defenseless against a headlong rush into the abyss of global warming, nuclear holocaust, and the other catastrophes that loom on our horizon. Reviving the religious anthropology of Max Weber, Emile Durkheim, and Marcel Mauss and in dialogue with the work of René Girard, Dupuy shows that we must remember the world's sacredness in order to keep human violence in check. A metaphysical and theological detective, he tracks the sacred in the very fields where human reason considers itself most free from everything it judges irrational: science, technology, economics, political and strategic thought. In making such claims, The Mark of the Sacred takes on religion bashers, secularists, and fundamentalists at once. Written by one of the deepest and most versatile thinkers of our time, it militates for a world where reason is no longer an enemy of faith. (shrink)

In a remarkable exchange between neuroscientist Jean-Pierre Changeux and philosopher Paul Ricoeur, this book explores the vexed territory between these...

Jean-Pierre Vernant delineates a compelling new vision of ancient Greece that takesus far from the calm and familiar images of Polykleitos and the Parthenon, and reveals a culture ofslavery, of blood sacrifice, of perpetual and ritualized warfare, of ceremonial hunting andecstasies.In his provocative discussions of various institutions and practices including war,marriage, and the city state, Vernant unveils a complex and previously unexplored intersection ofthe religious, social, and political structures of ancient Greece. He concludes with a genealogy ofthe study (...) of myth from antiquity to the present, and offers a critique of structuralism.Jean-PierreVernant is Professor Emeritus of Comparative Study of Ancient Religions at the College de France inParis. (shrink)

Jean-Pierre Boistel est percussionniste et Directeur pédagogique de l'École régionale de Jazz et des Musiques actuelles de Montpellier. Tous ses droits sont réservés. Aborder l'expression rythmique par le nombre d'impulsions : 1 : Un coup, un accent, une note, un son permet d'entendre immédiatement l'origine – le passage du silence, du vide (plein de potentiels) non déterminé à la résonance. Plaquer un accord et le laisser résonner ouvre le champ du chant musical et l'imagination de l'interprète (...) - (...) Musique et Musicologie – GALERIE – Nouvel article. (shrink)

Transhuman, or trans-human, is the concept of an intermediary form between human and posthuman. In other words, a transhuman is a being that resembles a human in most respects but who has powers and abilities beyond those of standard humans. These abilities might include improved intelligence, awareness, strength, or durability. Transhumans sometimes appear in science-fiction as cyborgs or genetically-enhanced humans. This book will look into the question "Can machines think?" followed by "Can humans extend their lifespan and keep up with (...) machines?" In other words, do we (humans) have to modify ourselves to be bionic humans, to co-exist and make the most of machines in future? (shrink)